Abstract #3845

Improved Efficiency of Free-Breathing Stack-of-Radial MRI for Liver Fat and R2* Quantification Using Accelerated k-space Shift Calibration

Xiaodong Zhong¹, Tess Armstrong^2,3, Chang Gao^2,3, Marcel Dominik Nickel⁴, Fei Han¹, Brian Dale⁵, Holden Wu^2,3, Peng Hu^2,3, and Vibhas Deshpande⁶

¹MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States, ²Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ³Physics and Biology in Medicine Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, United States, ⁴MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, ⁵MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Cary, NC, United States, ⁶MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Austin, TX, United States

For liver proton density fat fraction (PDFF) and R₂^* quantification, free-breathing three-dimensional stack-of-radial MRI may perform a calibration scan for k-space shift correction. This study proposes an accelerated k-space shift calibration method. The proposed method was validated in a PDFF/R₂^* phantom with vendor-provided ground truth. Preliminary in vivo results demonstrated good agreement in the liver PDFF/R₂^* compared to the reference breath-hold Cartesian MRI. This proposed method enabled a 3-fold reduction in calibration time (20 seconds or more) for the in vivo protocols in this study. It may allow more efficient free-breathing PDFF/R₂^* mapping in patient populations with breath-hold difficulties.

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