The measurement of R1rho (1/T1rho) spectrum and its asymmetry have several advantages over conventional CEST MTR asymmetry in probing chemical exchange effect. Previous studies have reported that AC-iTIP is a robust approach to obtain R1rho-spectrum and R1rho asymmetry. However, an accurate B0 map is required to perform R1rho asymmetry. In this work, we fit the entire R1rho spectrum to a mathematical expression and directly acquire the pool population parameter pb. A preliminary in vivo scan on 4 osteoarthritis patients was performed and AC-iTIP shows promising results in probing GAG content in knee cartilage at 3.0T.
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