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Abstract #4331

Agreement of CVR maps acquired using hypocapnic and hypercapnic breathing tasks

Kristina M. Zvolanek1,2, Rachael C. Stickland2, Stefano Moia3,4, Apoorva Ayyagari1,2, C├ęsar Caballero-Gaudes3, and Molly G. Bright1,2
1Biomedical Engineering, Northwestern University, Evanston, IL, United States, 2Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, United States, 3Basque Center on Cognition, Brain and Language, Donostia, [Gipuzkoa], Spain, 4University of the Basque Country EHU/UPV, Donostia, [Gipuzkoa], Spain

The addition of a breath-hold or deep breathing task to the beginning of a resting state fMRI scan is a feasible method for cerebrovascular reactivity (CVR) mapping. However, these two tasks rely on different physiological mechanisms with different temporal properties. We used a bespoke analysis method to account for voxelwise hemodynamic lag and assessed its impact on agreement between CVR measurements from each breathing task. Good agreement was observed both across the brain and across subjects, regardless of hemodynamic lag correction, indicating both tasks are comparable options for BOLD CVR measurements in healthy subjects.

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