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Abstract #4332

Effect of Myelin Content on Cognitive Outcomes in Cerebral Small Vessel Disease

Elizabeth Dao1, Roger Tam1, Ging-Yuek R Hsiung1, Lisanne ten Brinke1, Rachel Crockett1, Cindy K Barha1, Youngjin Yoo1, Walid al Keridy2, Stephanie H Doherty1, Alex L MacKay1, Cornelia Laule1, and Teresa Liu-Ambrose1
1University of British Columbia, Vancouver, BC, Canada, 2King Saud University, Riyadh, Saudi Arabia

Pathology studies report myelin damage as a salient feature in cerebral small vessel disease (cSVD). Currently, the role of myelin content in-vivo on cognition is poorly understood. Thus, the main purpose of this study was to investigate the association between myelin content and cognitive function in cSVD. Normal appearing white matter (NAWM) myelin water fraction (MWF) was quantified in 55 people with cSVD with spin-echo myelin water imaging. After accounting for age, education, and white matter hyperintensity volume, lower NAWM MWF was significantly associated with slower processing speed and poorer working memory, but not with set shifting or inhibitory control.

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