Abstract #4332

Effect of Myelin Content on Cognitive Outcomes in Cerebral Small Vessel Disease

Elizabeth Dao¹, Roger Tam¹, Ging-Yuek R Hsiung¹, Lisanne ten Brinke¹, Rachel Crockett¹, Cindy K Barha¹, Youngjin Yoo¹, Walid al Keridy², Stephanie H Doherty¹, Alex L MacKay¹, Cornelia Laule¹, and Teresa Liu-Ambrose¹

¹University of British Columbia, Vancouver, BC, Canada, ²King Saud University, Riyadh, Saudi Arabia

Pathology studies report myelin damage as a salient feature in cerebral small vessel disease (cSVD). Currently, the role of myelin content in-vivo on cognition is poorly understood. Thus, the main purpose of this study was to investigate the association between myelin content and cognitive function in cSVD. Normal appearing white matter (NAWM) myelin water fraction (MWF) was quantified in 55 people with cSVD with spin-echo myelin water imaging. After accounting for age, education, and white matter hyperintensity volume, lower NAWM MWF was significantly associated with slower processing speed and poorer working memory, but not with set shifting or inhibitory control.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.