Abstract #4333

Impaired cerebrovascular reactivity in patients with Huntington's disease

Suk-tak Chan¹, Nathaniel Mercaldo², Kenneth K. Kwong¹, Steven M. Hersch³, and Herminia D. Rosas³

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ³Department of Neurology, Massachusetts General Hospital, Boston, MA, United States

Multiple subcortical white matter areas showing impaired cerebrovascular reactivity (CVR) in our pre-symptomatic and early Huntington Disease (HD) subjects overlap with the white matter areas and tracts that have been reported to demonstrate altered microstructural integrity. They are also adjacent to cortical brain regions that atrophy as disease progresses in HD. Our findings support that abnormal cerebrovascular function contributes to the neuropathology of HD.

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