Abstract #4334

Quantification of Relative Blood Volume in Squirrel Monkey Brain in vivo using an MRI-based template

Zhangyan yang^1,2, Feng Wang^1,3, Chaohui Tang¹, Li Min Chen^1,3, and Gore C. John^1,2,3

¹Institute of Imaging Science, Vanderbilt University, Nashiville, TN, United States, ²Biomedical Engineering, Vanderbilt University, Nashiville, TN, United States, ³Department of Radiology and Radiological Science, Vanderbilt University, Nashiville, TN, United States

Cerebral blood volume (CBV) is a fundamental hemodynamic characteristic of brain related to blood flow and metabolism. High resolution (sub-millimeter) maps of relative values of CBV (rCBV) provide important information for studies of brain function and changes that occur in brain structure and organization. In this study, by using an intravascular superparamagnetic contrast agent in non-human primates, we quantified high-resolution rCBV maps across subjects, identified alterations of rCBV across regions, and created an rCBV atlas using a brain template.

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