Abstract #4335

Test–Retest Repeatability of Brain Oxygen Metabolism Measurement using MRI

Chunwei Ying¹, Michael M. Binkley², Peter Kang², Yasheng Chen², Jin-Moo Lee^2,3, Andria L. Ford², and Hongyu An³

¹Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States, ²Department of Neurology, Washington University School of Medicine, St. Louis, MO, United States, ³Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States

We evaluated the test-retest repeatability of MR-measurement of CBF, OEF and CMRO₂ in whole brain, gray matter, white matter, and watershed regions in healthy subjects. The inter-session wCV was 2.20% in white matter and 2.76% in watershed region for OEF measured with ASE, 15.02% in white matter and 28.73% in watershed region for CBF measured with 2D multi-slice pCASL, and 9.11% in white matter and 17.14% in watershed region for CBF measured with background suppressed 3D pCASL. CMRO₂ had similar test-retest repeatability to CBF.

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