Abstract #0054
Comparing high resolution 7T MRSI and PET of glioma – a promising correspondence of glutamine to amino acid PET
Gilbert Hangel1, Philipp Lazen2, Sukrit Sharma2, Barbara Hritoska3, Cornelius Cadrien1, Julia Furtner4, Ivo Rausch5, Tatjana Traub-Weidinger6, Eva Niess2, Lukas Hingerl2, Stephan Gruber2, Bernhard Strasser2, Barbara Kiesel7, Matthias Preusser8, Thomas Roetzer-Pejrimovsky9, Adelheid Woehrer9, Wolfgang Bogner2, Georg Widhalm7, Karl Rössler7, and Siegfried Trattnig2,10,11
1Department of Neurosurgery & High Field MR Centre, Medical University of Vienna, Wien, Austria, 2High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3FH Campus Wien University of Applied Sciences, Vienna, Austria, 4Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 5Center for Medical Physics and Biomedical Engineering,, Medical University of Vienna, Vienna, Austria, 6Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 7Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, 8Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria, 9Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria, 10Institute for Clinical Molecular MRI, Karl Landsteiner Society, St. Pölten, Austria, 11Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria
Synopsis
We compared metabolic ratio maps of tCho, Gln, and Gly to tNAA and tCr derived from high-resolution 7T MRSI to clinical amino acid PET in 24 glioma patients. We achieved the highest DICE coefficient of 0.66±0.25 for Gln/tNAA, and further defined hot spot volumes and center of intensity distances between PET and MRSI. Overall, we showed that the information content of 7T MRSI results in a better correspondence to PET as clinical gold standard than previous MRSI studies.
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