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Abstract #0071

Measuring glomerular blood transfer rate in kidney using diffusion-weighted arterial spin labeling

Hyun-Seo Ahn1 and Sung-Hong Park1
1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of


Imaging methods for the non-invasive measurement of renal function, such as glomerular filtration rate (GFR), are promising. In this study, we propose a renal perfusion kinetic model to estimate the blood transfer rate constant ($$$k_G$$$) in glomerulus with the multi-slice multi-delay diffusion-weighted arterial spin labeling sequence. Mean cortical $$$k_G$$$ values with a caffeine challenge were higher than those with no caffeine challenge, consistent with previous studies with GFR. The current study is promising in that it shows a potential availability of $$$k_G$$$ as a non-invasive quantitative measure of renal function.

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