Here we apply intravoxel incoherent motion (IVIM) and fractional Fickian diffusion (FFD) models to multi-b-value diffusion-weighted-MRI to study tissue cellular and resting microvascular properties of the foot of patients with diabetic foot ulcer. We report preliminary results from an ongoing study comparing patients with type 2 diabetes and persistent plantar foot ulcers with healthy age- and BMI-matched individuals. Pseudo-diffusion and mean diffusion coefficients and microvascular volume fraction were elevated in patients, showing large effect sizes in subregions. This approach may prove useful for evaluating patients with ulcers to prognosticate tissue at risk of poor wound healing.
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