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Abstract #0074

Elevated Foot Diffusion and Resting Perfusion in Patients with Diabetic Foot Ulcer: A Pilot and Feasibility Study

David A Reiter1, Jingting Yao2, Scott Edwards1, Marcos Coutinho Schechter1, Maya Fayfman1, Gabriel Santamarina1, Paula Nesbeth1, Vincent Giacalone1, Gerardo Blanco1, Thorsten Feiweier3, Rabindra Tirouvanziam1, Jessica Alvarez1, Benjamine Risk1, and Ravi Rajani1
1Emory University, Atlanta, GA, United States, 2Massachusetts General Hospital, Boston, MA, United States, 3Siemens Healthcare GmbH, Erlangen, Germany


Here we apply intravoxel incoherent motion (IVIM) and fractional Fickian diffusion (FFD) models to multi-b-value diffusion-weighted-MRI to study tissue cellular and resting microvascular properties of the foot of patients with diabetic foot ulcer. We report preliminary results from an ongoing study comparing patients with type 2 diabetes and persistent plantar foot ulcers with healthy age- and BMI-matched individuals. Pseudo-diffusion and mean diffusion coefficients and microvascular volume fraction were elevated in patients, showing large effect sizes in subregions. This approach may prove useful for evaluating patients with ulcers to prognosticate tissue at risk of poor wound healing.

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