Abstract #0075

Velocity-selective arterial spin labeling perfusion in the evaluation of treated high grade gliomas at 1.5 Tesla

Sebastian Lambrecht^1,2, Dapeng Liu^1,3, Omar Dzaye⁴, Matthias Holdhoff⁴, Peter van Zijl^1,3, Qin Qin^1,3, and Doris Lin^1,3

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Institute of Neuroradiology, University Hospital LMU Munich, Munich, Germany, ³F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Perfusion measures were compared between VSASL and DSC methods at 1.5T in 28 patients with treated high-grade glioma assigned into 2 groups: “tumor” (with detectable enhancing tumor, n=9) and “non-tumor” (without detectable tumor, n=19). All measures (rCBF and tSNR from VSASL, rCBV and rCBF from DSC) showed significant difference between “tumor” and “non-tumor” groups allowing reliable discrimination. In general, there was moderate to excellent agreement and correlation between these measures derived from VSASL vs. DSC. Hence, VSASL has potential to serve as a viable non-invasive alternative to DSC perfusion in the clinical disease surveillance without the need for exogenous contrast.

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