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Abstract #0101

3D Diffusion-prepared MRF (3DM) with cardiac gating for rapid high resolution whole-brain T1, T2, proton density and diffusivity mapping

Xiaozhi Cao1,2, Congyu Liao1,2, Zheng Zhong1, Erpeng Dai1, Siddharth Srinivasan Iyer1,3, Ariel J Hannum1,4, Mahmut Yurt1,2, Stefan Skare5, and Kawin Setsompop1,2
1Department of Radiology, Stanford university, Stanford, CA, United States, 2Department of Electrical Engineering, Stanford university, Stanford, CA, United States, 3Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States, 4Department of Bioengineering, Stanford university, Stanford, CA, United States, 5Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden


In this work, a diffusion preparation was implemented in a 3D spiral-projection MRF framework to introduce additional diffusion weighting. Using MRF dictionary with diffusion terms, it enables whole-brain T1, T2, PD and additional diffusivity mapping with 1.25-mm isotropic resolution within 3min. To improve the image quality, cardiac gating and low-resolution navigator were also implemented to mitigate the signal variation caused by motion during diffusion encoding. Subspace reconstruction was used along with LLR regularization to improve the reconstruction conditioning as well as SNR.

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