In this work, a diffusion preparation was implemented in a 3D spiral-projection MRF framework to introduce additional diffusion weighting. Using MRF dictionary with diffusion terms, it enables whole-brain T1, T2, PD and additional diffusivity mapping with 1.25-mm isotropic resolution within 3min. To improve the image quality, cardiac gating and low-resolution navigator were also implemented to mitigate the signal variation caused by motion during diffusion encoding. Subspace reconstruction was used along with LLR regularization to improve the reconstruction conditioning as well as SNR.
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