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Abstract #0116

Free-Breathing Liver QSM with High Isotropic Resolution Using Respiratory Motion-Resolved 3D Multi-Echo Cones MRI

MungSoo Kang1,2, Ramin Jafari1, Gerald G. Behr3, Ricardo Otazo1,3, and Youngwook Kee1
1Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of, 3Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States


Liver quantitative susceptibility mapping (QSM) can provide a direct measurement of liver iron concentration (LIC). However, respiratory motion and rapid T2* decay are the major challenges in reliable liver QSM. To address these issues a motion-resolved multi-echo 3D cones MRI method with pseudo-random view ordering was implemented, which was then compared with a multi-echo Cartesian GRE sequence in a phantom and healthy volunteer. The proposed motion-resolved cones QSM presented strong motion-robustness in terms of image quality and ROI-based measurements in our phantom and in-vivo studies, demonstrating the feasibility of free-breathing liver QSM.

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