Liver quantitative susceptibility mapping (QSM) can provide a direct measurement of liver iron concentration (LIC). However, respiratory motion and rapid T2* decay are the major challenges in reliable liver QSM. To address these issues a motion-resolved multi-echo 3D cones MRI method with pseudo-random view ordering was implemented, which was then compared with a multi-echo Cartesian GRE sequence in a phantom and healthy volunteer. The proposed motion-resolved cones QSM presented strong motion-robustness in terms of image quality and ROI-based measurements in our phantom and in-vivo studies, demonstrating the feasibility of free-breathing liver QSM.
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