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Abstract #0118

Imaging the pulsatile fluid source distribution and pressure gradients in the brain using a poroelastic model and intrinsic pulsatile motions.

Matthew McGarry1, John Weaver1,2, and Keith Paulsen1,2
1Dartmouth College, Hanover, NH, United States, 2Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States


The pulsatile tissue motions from the cardiac cycle can be imaged using retrospectively gated phase contrast MRI. Modeling brain tissue as a poroelastic material allows a distribution of pulsatile fluid sources to be computed which reproduce the measured motions by estimating the RHS vector of a finite element representation of the poroelastic system. This Fluid source imaging (FSI) represents a completely new type of image parameterization that could offer unique diagnostic signatures. The associated pressure field gradients are also the driving force for interstitial fluid movement, where disruptions are thought to cause buildup of waste products which leads to dementia.

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