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Abstract #0119

Influence of hepatic tissue water content on MRE-based biomarkers in clinical and preclinical studies

Jiahui Li1, Zheng Zhu1, Jingbiao Chen1, Alina M Allen2, Sudhakar K. Venkatesh1, Taofic Mounajjed3, Kevin J. Glaser1, Armando Manduca1, Vijay H. Shah2, Richard L. Ehman1, and Meng Yin1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States, 3Anatomic Pathology, Mayo Clinic, Rochester, MN, United States


The water in hepatic tissue has intracellular, extracellular matrix bound, and extracellular interstitial free fluid components, which are affected by inflammation and fibrosis. This study assessed longitudinal changes in MRE-based biomarkers and their relationship with hepatic water content in clinical and preclinical models. In clinical studies, MRE-assessed loss modulus (LM) was elevated in obese patients and in NAFLD patients with severe inflammation. In preclinical models, changes in LM correlated with water content and disease progression in non-NAFLD mice. LM significantly increased with the development of NASH. MRE-assessed viscoelasticity strongly reflects extracellular free fluid associated with inflammation.

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