Abstract #0120

Microvascular invasion in patients with hepatocellular carcinoma: assessment with compression MR elastography

Gwenaël Pagé¹, Philippe Garteiser¹, Valérie Paradis², Ralph Sinkus³, Valérie Vilgrain^1,4, and Bernard E. Van Beers^1,4

¹Laboratory of imaging biomarkers, INSERM UMR 1149, Paris, France, ²Center for research on inflammation, INSERM UMR 1149, Paris, France, ³Laboratory for vascular translational science, INSERM UMR 1148, Paris, France, ⁴Department of Radiology, University Hospital Paris Nord, Clichy, France

Synopsis

The aim of this study was to investigate the value of compression MR elastography to assess microvascular invasion in hepatocellular carcinomas. MR elastographic and T2-weighted images were acquired at end expiration and end inspiration in 52 patients with hepatocellular carcinomas. The storage and loss moduli at inspiration did not differ between tumors with/without microvascular invasion. However, the compression stiffening rate, derived from the increase of tumor storage modulus between expiration and inspiration, had good diagnostic performance (area under the receiver operating characteristic curve 0.85) in detecting microvascular invasion.

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