Abstract #0121

Self-Navigated Radial Free-Breathing Magnetic Resonance Elastography of the Liver with Rapid Motion Encoding in Children at 3T

Sevgi Gokce Kafali^1,2, Bradley D. Bolster Jr.³, Shu-Fu Shih^1,2, Grace J. Kim¹, Joanna Yeh⁴, Robert S. Venick⁴, Shahnaz Ghahremani¹, Kara L. Calkins⁴, and Holden H. Wu^1,2

¹Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³MR Collaborations, Siemens Medical Solutions, Inc., Salt Lake City, UT, United States, ⁴Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States

Synopsis

Hepatic stiffness measured by magnetic resonance elastography (MRE) is a biomarker for hepatic fibrosis. Conventional Cartesian gradient-echo MRE requires breath-holding (BH), which can be challenging for children. While radial free-breathing (FB) MRE overcomes the challenge of BH, the scan time is relatively longer (163 seconds/slice). This study’s objective was to reduce radial FB-MRE scan time by a factor of two with rapid motion encoding (81 seconds/slice) and to improve robustness by performing self-navigated motion compensation. Compared to Cartesian BH-MRE in children at 3T, the proposed rapid radial FB-MRE technique quantified hepatic stiffness with close agreement and similar repeatability.

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