Self-Navigated Radial Free-Breathing Magnetic Resonance Elastography of the Liver with Rapid Motion Encoding in Children at 3T
Sevgi Gokce Kafali1,2, Bradley D. Bolster Jr.3, Shu-Fu Shih1,2, Grace J. Kim1, Joanna Yeh4, Robert S. Venick4, Shahnaz Ghahremani1, Kara L. Calkins4, and Holden H. Wu1,2
1Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3MR Collaborations, Siemens Medical Solutions, Inc., Salt Lake City, UT, United States, 4Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States
Hepatic stiffness measured by magnetic resonance elastography (MRE) is a biomarker for hepatic fibrosis. Conventional Cartesian gradient-echo MRE requires breath-holding (BH), which can be challenging for children. While radial free-breathing (FB) MRE overcomes the challenge of BH, the scan time is relatively longer (163 seconds/slice). This study’s objective was to reduce radial FB-MRE scan time by a factor of two with rapid motion encoding (81 seconds/slice) and to improve robustness by performing self-navigated motion compensation. Compared to Cartesian BH-MRE in children at 3T, the proposed rapid radial FB-MRE technique quantified hepatic stiffness with close agreement and similar repeatability.
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