Early tumour response to radiotherapy assessed by magnetic resonance elastography
Clementine Lesbats1, Upasana Roy1, Emma L. Reeves1, Jessica K. R. Boult1, Yann Jamin2, Craig Cummings1, James Sullivan3, Ralph Sinkus4, Erik Wennerberg1, and Simon P. Robinson2
1Division of Radiotherapy & Imaging, The Institute of Cancer Research, Sutton, United Kingdom, 2The Institute of Cancer Research, Sutton, United Kingdom, 3The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom, 4School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
Radiotherapy is widely used to treat cancer. In this study, we used MR elastography to evaluate early tumour response to radiation therapy. A significant increase in stiffness |G*| and elasticity Gd were determined 3 days after orthotopic 4T1 breast tumours were irradiated with a single 8Gy dose, compared to untreated control tumour-bearing mice. The increase in tumour stiffness was associated with an increased macromolecule pool measured by magnetisation transfer, and increased collagen deposition observed histologically.
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