High-Resolution Compressed Sensing 19F-MRI Reveals Progression of Neuroinflammation in Autoimmune Encephalomyelitis
Ludger Starke1,2, Paula Ramos Delgado1, Jason M. Millward1, Sabrina Klix1, Thoralf Niendorf1,3, and Sonia Waiczies1
1Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2Digital Health Center, Hasso Plattner Institute, Potsdam, Germany, 3Experimental and Clinical Research Center (ECRC), A Joint Cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany
Improving sensitivity has been the major challenge towards realizing the promises of 19F-MRI. Here we combine a cryogenic surface RF probe and compressed sensing to achieve high spatially resolved 19F-MRI of neuroinflammation in a challenging longitudinal study. Inflammation in the CNS was observed even in the absence of neurological symptoms and detailed signals along the CNS vasculature are clearly resolved. Together with effective longitudinal registration this allows an in-depth study of disease progression.
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