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Abstract #0134

Neuronal Response to Transcranial Direct Current Stimulation (tDCS) in Multiple Sclerosis

Marco Muccio1, Lillian Walton Masters2, Giuseppina Pilloni2, Lauren Krupp2, Abhishek Datta3, Marom Bikson4, Leigh Charvet2, and Yulin Ge1
1Radiology, NYU Grossman School of Medicine, New York City, NY, United States, 2Neurology, NYU Grossman School of Medicine, New York City, NY, United States, 3Soterix Medical Inc., New York City, NY, United States, 4Department of Biomedical Engineering, City College of New York, New York City, NY, United States


Transcranial direct current stimulation (tDCS) represents an innovative therapeutic tool for neurological diseases such as multiple sclerosis (MS). In this study, MRI measurements of cerebral blood flow (CBF), venous oxygenation (Yv) and cerebral metabolic rate of oxygen (CMRO2) of MS patients and healthy controls (HCs) were acquired pre-, during- and post-tDCS to investigate its simultaneous effects. Whilst HCs showed an immediate increase (~5%) in CMRO2 (during- versus pre-tDCS, p<0.001), MS patients showed a delayed response to tDCS (7.7% CMRO2 increase pre- versus post-tDCS; p=0.007). We suggest that neuronal response to tDCS represents a potential biomarker of neuronal plasticity.

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