Abstract #0134

Neuronal Response to Transcranial Direct Current Stimulation (tDCS) in Multiple Sclerosis

Marco Muccio¹, Lillian Walton Masters², Giuseppina Pilloni², Lauren Krupp², Abhishek Datta³, Marom Bikson⁴, Leigh Charvet², and Yulin Ge¹

¹Radiology, NYU Grossman School of Medicine, New York City, NY, United States, ²Neurology, NYU Grossman School of Medicine, New York City, NY, United States, ³Soterix Medical Inc., New York City, NY, United States, ⁴Department of Biomedical Engineering, City College of New York, New York City, NY, United States

Synopsis

Transcranial direct current stimulation (tDCS) represents an innovative therapeutic tool for neurological diseases such as multiple sclerosis (MS). In this study, MRI measurements of cerebral blood flow (CBF), venous oxygenation (Yv) and cerebral metabolic rate of oxygen (CMRO2) of MS patients and healthy controls (HCs) were acquired pre-, during- and post-tDCS to investigate its simultaneous effects. Whilst HCs showed an immediate increase (~5%) in CMRO2 (during- versus pre-tDCS, p<0.001), MS patients showed a delayed response to tDCS (7.7% CMRO2 increase pre- versus post-tDCS; p=0.007). We suggest that neuronal response to tDCS represents a potential biomarker of neuronal plasticity.

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