Understanding the cause and progress of remyelination in MS is critical for developing potential therapeutic targets of remyelination to restore neural connectivity and brain functions. In this study, we utilized a novel MRI-based oxygen extraction fraction (OEF) mapping method, namely “QQ”, and found that early lesion oxygen metabolism increase, as measured by QQ-based OEF, is positively associated with lesion myelin recovery, as measured by myelin water fraction. This study suggests that QQ-based OEF mapping may be a useful tool readily and widely available for studying MS lesion oxygen metabolism and its association with MS lesion remyelination.
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