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Abstract #0136

Increased oxygen extraction fraction following acute multiple sclerosis (MS) lesion formation is associated with increased myelin repair.

Junghun Cho1, Thanh D Nguyen1, Lily Zexter1, Elizabeth M Sweeney2, Pascal Spincemaille1, Ajay Gupta1, Susan A Gauthier1, and Yi Wang1,3
1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Population Health Sciences, Weill Cornell Medicine, New York, NY, United States, 3Biomedical Engineering, Cornell University, Ithaca, NY, United States


Understanding the cause and progress of remyelination in MS is critical for developing potential therapeutic targets of remyelination to restore neural connectivity and brain functions. In this study, we utilized a novel MRI-based oxygen extraction fraction (OEF) mapping method, namely “QQ”, and found that early lesion oxygen metabolism increase, as measured by QQ-based OEF, is positively associated with lesion myelin recovery, as measured by myelin water fraction. This study suggests that QQ-based OEF mapping may be a useful tool readily and widely available for studying MS lesion oxygen metabolism and its association with MS lesion remyelination.

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