Abstract #0137

Imaging multiple sclerosis histopathology using susceptibility source separation: a postmortem brain study

Hyeong-Geol Shin¹, Riccardo Galbusera^2,3, Jincheol Seo⁴, Sooyeon Ji¹, Erik Bahn⁵, Jonas Franz⁵, Christine Stadelmann-Nessler⁵, Po-Jui Lu², Jinhee Jang⁶, Youngjeon Lee⁴, Cristina Granziera², and Jongho Lee¹

¹Department of Electrical and Computer engineering, Seoul National University, Seoul, Korea, Republic of, ²Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland, ³MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, ⁴National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Korea, Republic of, ⁵Institute of Neuropathology, University Medical Center, Göttingen, Germany, ⁶Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of

Synopsis

The pathology of multiple sclerosis (MS) is highly correlated with the dynamics of two susceptibility sources, paramagnetic iron and diamagnetic myelin. Various MRI methods sensitive to the substances have been developed for MS pathology. However, the collective effects of iron and myelin to an MRI signal have hampered monitoring individual changes of the substances. Here, we evaluated the effectiveness of 𝜒-separation, which estimates individual contributions of para-/dia-magnetic susceptibility, for visualizing MS pathology-related iron/myelin changes. The resulting paramagnetic and diamagnetic susceptibility conform to the histopathological features of MS lesion (iron-rim in Perls staining, and re-/de-myelinated lesions in myelin basic protein staining).

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.