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Abstract #0137

Imaging multiple sclerosis histopathology using susceptibility source separation: a postmortem brain study

Hyeong-Geol Shin1, Riccardo Galbusera2,3, Jincheol Seo4, Sooyeon Ji1, Erik Bahn5, Jonas Franz5, Christine Stadelmann-Nessler5, Po-Jui Lu2, Jinhee Jang6, Youngjeon Lee4, Cristina Granziera2, and Jongho Lee1
1Department of Electrical and Computer engineering, Seoul National University, Seoul, Korea, Republic of, 2Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland, 3MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, 4National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Korea, Republic of, 5Institute of Neuropathology, University Medical Center, Göttingen, Germany, 6Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of


The pathology of multiple sclerosis (MS) is highly correlated with the dynamics of two susceptibility sources, paramagnetic iron and diamagnetic myelin. Various MRI methods sensitive to the substances have been developed for MS pathology. However, the collective effects of iron and myelin to an MRI signal have hampered monitoring individual changes of the substances. Here, we evaluated the effectiveness of 𝜒-separation, which estimates individual contributions of para-/dia-magnetic susceptibility, for visualizing MS pathology-related iron/myelin changes. The resulting paramagnetic and diamagnetic susceptibility conform to the histopathological features of MS lesion (iron-rim in Perls staining, and re-/de-myelinated lesions in myelin basic protein staining).

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