Looking for a differential vulnerability of specific thalamic nuclei in multiple sclerosis
Simon Blyau1, Ismail Koubiyr1, Pierrick Coupé2, Manoj Saranathan3, Julie Charré-Morin4, Aurore Saubusse4, Valentin Prevost5, Bei Zhang6, Mathilde Deloire4, Bruno Brochet1, Aurélie Ruet1, and Thomas Tourdias1
1Neurocentre Magendie, Bordeaux, France, 2Laboratoire Bordelais de Recherche en Informatique, TALENCE, France, 3University of Arizona, Tucson, AZ, United States, 4Neurology Department, Hopital Pellegrin, Bordeaux, France, Metropolitan, 5Canon Medical System Corporation, Tochigi, Japan, 6Canon Medical System Europe, Paris, France
Thalamus is one of the first grey matter structure affected in multiple sclerosis (MS). It could undergo a differential vulnerability predominating on nuclei closer to the third ventricle due to pro-inflammatory factors brought by cerebrospinal fluid.First, we validated an atlas-based segmentation method that enables thalamic segmentation over conventional T1 weighted images. Then, using this segmentation method, we brought evidence for a medio-lateral gradient of thalamic atrophy in MS. While less affected, the anterior group was found useful to distinguish cognitively preserved from cognitively impaired patients. This paves the way toward more thalamic nuclei analyses in MS as new biomarkers.
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