Abstract #0139

Lesion-specific Metabolic Fingerprinting in Relapsing-Remitting Multiple Sclerosis via 7T Magnetic Resonance Spectroscopic Imaging

Alexandra Lipka¹, Eva Heckova¹, Assunta Dal-Bianco², Gilbert Hangel^1,3, Paulus S. Rommer², Bernhard Strasser¹, Stanislav Motyka¹, Lukas Hingerl¹, Thomas Berger², Petra Hnilicová⁴, Ema Kantorová⁵, Fritz Leutmezer², Egon Kurča⁵, Stephan Gruber¹, Siegfried Trattnig^1,6, and Wolfgang Bogner¹

¹High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Department of Neurology, Medical University of Vienna, Vienna, Austria, Vienna, Austria, ³Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, Vienna, Austria, ⁴Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, ⁵Clinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, ⁶Karl Landsteiner Institute for Clinical Molecular MRI in Musculoskeletal System, Vienna, Austria

Synopsis

Conventional T1/T2-weighted magnetic resonance imaging (cMRI) is the method of choice for diagnosis and treatment monitoring of multiple sclerosis (MS), though not being able to explain underlying pathological processes. In contrast to cMRI-lesions, which only reflect the severity of irreversible tissue damage, MR Spectroscopic Imaging (MRSI) can detect pathologies on a biochemical level. In 51 relapsing-remitting (RRMS) patients, we investigate - enabled through ultra-high resolution FID-MRSI at 7T - the metabolic distribution within lesions and their vicinity as well as their location dependency and correlation to T1-hypointensity.

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