Abstract #0139
Lesion-specific Metabolic Fingerprinting in Relapsing-Remitting Multiple Sclerosis via 7T Magnetic Resonance Spectroscopic Imaging
Alexandra Lipka1, Eva Heckova1, Assunta Dal-Bianco2, Gilbert Hangel1,3, Paulus S. Rommer2, Bernhard Strasser1, Stanislav Motyka1, Lukas Hingerl1, Thomas Berger2, Petra Hnilicová4, Ema Kantorová5, Fritz Leutmezer2, Egon Kurča5, Stephan Gruber1, Siegfried Trattnig1,6, and Wolfgang Bogner1
1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of Neurology, Medical University of Vienna, Vienna, Austria, Vienna, Austria, 3Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, Vienna, Austria, 4Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, 5Clinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, 6Karl Landsteiner Institute for Clinical Molecular MRI in Musculoskeletal System, Vienna, Austria
Synopsis
Conventional T1/T2-weighted magnetic resonance imaging (cMRI) is the method of choice for diagnosis and treatment monitoring of multiple sclerosis (MS), though not being able to explain underlying pathological processes. In contrast to cMRI-lesions, which only reflect the severity of irreversible tissue damage, MR Spectroscopic Imaging (MRSI) can detect pathologies on a biochemical level. In 51 relapsing-remitting (RRMS) patients, we investigate - enabled through ultra-high resolution FID-MRSI at 7T - the metabolic distribution within lesions and their vicinity as well as their location dependency and correlation to T1-hypointensity.
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