Gauging tumour pressure and vasculature organization via Magnetic Resonance Elastography to grade brain tumours.
Giacomo Annio1,2, Robin Bugge3, Siri Fløgstad Svensson3, Omar Darwish4, Giorgio Seano5, Donata Biernat6, Karoline Skogen6, Jon Ramm-Pettersen 7, David Nordsletten8, Einar Vik-Mo 7, Katharina Schregel9, Kyrre Eeg Emblem3, and Ralph Sinkus1
1LVTS - U1148, University Paris, Paris, France, 2School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 3Department of Diagnostic Physics, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, 4Department of Biomedical Engineering, King's College London, London, United Kingdom, 5U1021 INSERM, Institut Curie, Paris, France, 6Department of Radiology Ullevål, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, 7Department of Neurosurgery, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway, 8Department of Biomedical Engineering and Cardiac Surgery, University of Michigan, Ann Arbor, MI, United States, 9Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany
Distinctive traits of malignant tumours are abnormal angiogenesis and high pressure. Conventional magnetic resonance imaging (MRI) plays a critical role in radiological evaluation of patients and tumour grading, but challenges remain. Pressure and vasculature have a strong impact on the tissue rheology and therefore they can be quantified by Magnetic Resonance Elastography (MRE). We show that MRE allows to quantify non-invasively tumour grade using pressure and tumour vasculature through wave scattering. We believe that MRE could play a central role in tumour grading and diagnosis as well as in therapy planning and dosage, especially in multidrug treatments scenarios.
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