Abstract #0443

Gauging tumour pressure and vasculature organization via Magnetic Resonance Elastography to grade brain tumours.

Giacomo Annio^1,2, Robin Bugge³, Siri Fløgstad Svensson³, Omar Darwish⁴, Giorgio Seano⁵, Donata Biernat⁶, Karoline Skogen⁶, Jon Ramm-Pettersen ⁷, David Nordsletten⁸, Einar Vik-Mo ⁷, Katharina Schregel⁹, Kyrre Eeg Emblem³, and Ralph Sinkus¹

¹LVTS - U1148, University Paris, Paris, France, ²School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ³Department of Diagnostic Physics, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, ⁴Department of Biomedical Engineering, King's College London, London, United Kingdom, ⁵U1021 INSERM, Institut Curie, Paris, France, ⁶Department of Radiology Ullevål, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, ⁷Department of Neurosurgery, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway, ⁸Department of Biomedical Engineering and Cardiac Surgery, University of Michigan, Ann Arbor, MI, United States, ⁹Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany

Synopsis

Distinctive traits of malignant tumours are abnormal angiogenesis and high pressure. Conventional magnetic resonance imaging (MRI) plays a critical role in radiological evaluation of patients and tumour grading, but challenges remain. Pressure and vasculature have a strong impact on the tissue rheology and therefore they can be quantified by Magnetic Resonance Elastography (MRE). We show that MRE allows to quantify non-invasively tumour grade using pressure and tumour vasculature through wave scattering. We believe that MRE could play a central role in tumour grading and diagnosis as well as in therapy planning and dosage, especially in multidrug treatments scenarios.

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