Abstract #0446

Quantitative assessment of cerebral oxygen extraction fraction (OEF) in the medial temporal lobe

Dengrong Jiang¹, Peiying Liu^1,2, Zixuan Lin¹, Abhay Moghekar³, Jay J. Pillai^1,4, and Hanzhang Lu^1,5,6

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ³Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

Synopsis

The medial temporal lobe (MTL), including the hippocampus, is a key area implicated in many brain diseases, such as Alzheimer’s disease. Since neural activity is tightly coupled to the brain’s oxygen consumption, oxygen-extraction-fraction (OEF) in the MTL (MTL-OEF) may serve as a functional biomarker for this critical region. In this work, we developed a novel non-invasive MRI technique, AS-aTRUPC, to specifically measure the MTL-OEF in the human brain. We found that in healthy volunteers, the MTL-OEF is lower than the cortical OEF. The sensitivity of our technique in detecting changes in MTL-OEF was demonstrated in caffeine challenge experiments.

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