Abstract #0446
Quantitative assessment of cerebral oxygen extraction fraction (OEF) in the medial temporal lobe
Dengrong Jiang1, Peiying Liu1,2, Zixuan Lin1, Abhay Moghekar3, Jay J. Pillai1,4, and Hanzhang Lu1,5,6
1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States
Synopsis
The medial temporal lobe (MTL), including the hippocampus, is a key area implicated in many brain diseases, such as Alzheimer’s disease. Since neural activity is tightly coupled to the brain’s oxygen consumption, oxygen-extraction-fraction (OEF) in the MTL (MTL-OEF) may serve as a functional biomarker for this critical region. In this work, we developed a novel non-invasive MRI technique, AS-aTRUPC, to specifically measure the MTL-OEF in the human brain. We found that in healthy volunteers, the MTL-OEF is lower than the cortical OEF. The sensitivity of our technique in detecting changes in MTL-OEF was demonstrated in caffeine challenge experiments.
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