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Abstract #0541

Large-scale Analysis of Meniscus Morphology as Risk Factor to Incidence of Osteoarthritis

Kenneth T Gao1,2, Emily Xie1, Vincent Chen1, Francesco Caliva1, Claudia Iriondo1, Richard B Souza1, Sharmila Majumdar1, and Valentina Pedoia1
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2University of California, Berkeley-University of California San Francisco Graduate Program in Bioengineering, Berkeley, CA, United States


While meniscal morphology is central to its capacity for weight distribution and stabilization in the knee joint, the relationship between the geometric shape of the meniscus and osteoarthritis is relatively unexplored. With 4,791 subjects from the Osteoarthritis Initiative, this study utilizes an automatic statistical shape modeling technique to identify variations in meniscus morphology as precursors to future development of osteoarthritis. Seven of the 20 shape features extracted were found to be significantly associated with osteoarthritis incidence. These features were further characterized with local changes in cartilage thickness across 8 years.

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