In addition to fat fraction (FF), muscular T2 could provide information on disease progression and potential training effects in osteosarcopenia, a combination of osteoporosis and sarcopenia. However, muscular T2 is highly dependent on the amount of muscle fat infiltration, which is usually increased in these patients. Thus, we aimed to assess T2 in thigh muscle tissue of elderly men with osteosarcopenia, comparing vendor-provided T2 maps with custom-fitted approaches also considering fat infiltration. We found highly elevated T2 values in the vendor-provided T2 maps compared to tri-exponentially fitted T2, which might lead to misinterpretation of muscle T2.
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