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Abstract #0601

Diagnostic performance of magnetic resonance elastography in mice with NASH and significant metabolic liver disease.

Meryem KHALFALLAH1, Sabrina Doblas1, Felicia Julea1, Catherine Postic2, Dominique Valla3, Valérie Paradis3,4, Philippe Garteiser1, and Bernard Van Beers1,5
1Université de Paris, Laboratory of Imaging Biomarkers, Center of Research on Inflammation, UMR 1149, Inserm, F-75018 Paris, France, Paris, France, 2Université de Paris, Institut Cochin, CNRS, INSERM, Paris, France., Paris, France, 3Service d’hépatologie et UMR1149, Hôpital Beaujon, Clichy-la-Garenne ; APHP, Université de Paris et Inserm, Clichy-la-Garenne, France, 4Diderot, CNRS, Centre de Recherche sur l'Inflammation (CRI), Paris, F-75890, France., Paris, France, 5Department of Radiology, AP-HP, Beaujon University Hospital Paris Nord, F-92110 Clichy, France, Clichy, France


Nonalcoholic steatohepatitis (NASH) and significant metabolic liver disease (MLD) are progressive forms of nonalcoholic fatty liver disease (NAFLD). MR elastography parameters have been shown to be useful for assessing NAFLD/NASH and liver inflammation. To assess the role of viscoelastic parameters in diagnosing NASH and significant MLD, MRE hepatic examinations were performed in mice with NAFLD. Our results showed that the diagnostic performance of MR elastography was higher in significant MLD than in NASH. This may be explained by inflammation and fibrosis occurring in indeterminate NASH cases included in MLD, and by poor performance of MR elastography to detect hepatocyte ballooning.

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