Abstract #0601

Diagnostic performance of magnetic resonance elastography in mice with NASH and significant metabolic liver disease.

Meryem KHALFALLAH¹, Sabrina Doblas¹, Felicia Julea¹, Catherine Postic², Dominique Valla³, Valérie Paradis^3,4, Philippe Garteiser¹, and Bernard Van Beers^1,5

¹Université de Paris, Laboratory of Imaging Biomarkers, Center of Research on Inflammation, UMR 1149, Inserm, F-75018 Paris, France, Paris, France, ²Université de Paris, Institut Cochin, CNRS, INSERM, Paris, France., Paris, France, ³Service d’hépatologie et UMR1149, Hôpital Beaujon, Clichy-la-Garenne ; APHP, Université de Paris et Inserm, Clichy-la-Garenne, France, ⁴Diderot, CNRS, Centre de Recherche sur l'Inflammation (CRI), Paris, F-75890, France., Paris, France, ⁵Department of Radiology, AP-HP, Beaujon University Hospital Paris Nord, F-92110 Clichy, France, Clichy, France

Synopsis

Nonalcoholic steatohepatitis (NASH) and significant metabolic liver disease (MLD) are progressive forms of nonalcoholic fatty liver disease (NAFLD). MR elastography parameters have been shown to be useful for assessing NAFLD/NASH and liver inflammation. To assess the role of viscoelastic parameters in diagnosing NASH and significant MLD, MRE hepatic examinations were performed in mice with NAFLD. Our results showed that the diagnostic performance of MR elastography was higher in significant MLD than in NASH. This may be explained by inflammation and fibrosis occurring in indeterminate NASH cases included in MLD, and by poor performance of MR elastography to detect hepatocyte ballooning.

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