Abstract #0602
Histological correlates of DR-HIGADOS microstructural metrics in the mouse and human liver
Francesco Grussu1, Kinga Bernatowicz1, Ignasi Barba2, Irene Casanova-Salas3, Natalia Castro3, Marco Palombo4, Sara Simonetti3,5, Juan Francisco Corral6,7, Marta Vidorreta8, Xavier Merino6,7, Richard Mast6,7, Núria Roson6,7, Manuel Escobar Amores6,7, Nahúm Calvo‐Malvar6,9, Josep R. Garcia-Bennett9, Rodrigo A. Toledo10, Joaquin Mateo3, Paolo Nuciforo5, Elena Garralda11, and Raquel Perez-Lopez1,7
1Radiomics Group, Vall d'Hebron Institute of Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain, 2NMR Lab, Vall d'Hebron Institute of Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain, 3Prostate Cancer Translational Research Group, Vall d'Hebron Institute of Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain, 4Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom, 5Molecular Oncology Group, Vall d'Hebron Institute of Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain, 6Institut de Diagnòstic per la Imatge (IDI), Catalonia, Spain, 7Department of Radiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain, 8Siemens Healthineers, Madrid, Spain, 9Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain, 10Gastrointestinal and Endocrine Tumors Group, Vall d'Hebron Institute of Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain, 11Early Clinical Drug Development Group, Vall d'Hebron Institute of Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain
Synopsis
“Diffusion-Relaxation Hepatic Imaging via Generalised Assessment of DiffusiOn Simulations” (DR-HIGADOS) is a recent liver diffusion MRI method for intra-cellular fraction, cell size and cellularity measurement. Here we compare DR-HIGADOS metrics to counterparts from histology in two data sets: i) preclinical 9.4T MRI of formalin-fixed patient-derived xenograft mouse livers, with co-localised histological sections; ii) clinical 1.5T in vivo MRI of metastatic and primary liver cancer patients, with co-localised biopsies. Results confirm that DR-HIGADOS cell size and cellularity are histologically meaningful, paving the way to the application of the new technique in clinical studies.
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