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Abstract #0603

Free-Breathing, 3D Phase Sensitive Inversion Recovery T1-Weighted MRI of the Liver

Yavuz Muslu1,2, Ty A. Cashen3, Sagar Mandava4, and Scott B. Reeder1,2,5,6,7
1Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3GE Healthcare, Waukesha, WI, United States, 4GE Healthcare, Atlanta, GA, United States, 5Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 6Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, 7Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Gadoxetic acid (GA)-enhanced hepatobiliary phase T1-weighted (HBP-T1w)-MRI is widely used in the clinical setting for detection of focal liver lesions (FLLs). However, complete characterization of liver lesions also requires T2w, diffusion weighted (DWI) and dynamic contrast enhanced (DCE) imaging. These methods often have inferior image spatial resolution compared to GA-enhanced HBP-T1w and may be unable to resolve small (<1cm) lesions visible only on HBP-T1w. In this work, we propose a novel phase sensitive inversion recovery (PSIR) T1w-MRI in combination with 3D radial stack-of-stars imaging and model-based water/fat separation for improved detection and characterization of small FLLs.

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