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Abstract #0604

The association of Liver Stiffness with Liver tissue T1 and Superior Mesenteric Artery blood flow across disease severity.

Christopher R Bradley1,2, Deirdre Mcgrath1,2, Eleanor F Cox1,2, Naaventhan Palaniyappan2, Robert Scott2, Indra N Guha2, Guruprasad P Aithal2, and Susan T Francis1,2
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2NIHR Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom


We assess liver stiffness measured using magnetic resonance elastography (MRE) and longitudinal relaxation time T1 in three groups: healthy volunteers, non-alcoholic fatty liver disease patients and compensated cirrhosis patients. MRE liver stiffness was measured using the Quantitative Imaging Biomarker Alliance (QIBA) recommendation. T1 longitudinal relaxation time of the liver was measured using a respiratory triggered inversion recovery fat-suppressed spin-echo echo planar imaging scheme. A positive correlation between Liver tissue T1 and Liver stiffness (R=0.70, p<0.0001) across the 3 groups was observed. Superior mesenteric artery flow also correlates with liver stiffness (R=0.62, p<0.002) suggesting worsening hyperdynamic circulation with progressive fibrosis.

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