Abstract #0735

Lung perfusion disturbances detected with MRI in non-hospitalized post-COVID individuals with dyspnea, with sex difference.

Jimmy Zhou Yu^1,2, Tobias Granberg^2,3, Roya Shams², Sven Petersson², Adrian Szum², Magnus Sköld⁴, Sven Nyrén^1,2, and Johan Lundberg^2,3

¹Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm Solna, Sweden, ²Radiology department, Karolinska University Hospital, Stockholm, Sweden, ³Department of Neuroscience, Karolinska Institutet, Stockholm Solna, Sweden, ⁴Department of Medicine, Karolinska Institutet, Stockholm Solna, Sweden

Synopsis

Mechanisms underlying dyspnea in non-hospitalized patients with persistent post-COVID is unknown. Lung perfusion abnormalities have been reported in acute COVID-19, and may also be important in post-COVID. Dynamic contrast enhanced (DCE)-MRI [MS1] was applied to study lung perfusion in 28 non-hospitalized patients with persistent dyspnea 4-13 months post-COVID. Time-to-peak (TTP)[MS2] maps were numerically summarized as normalized as 2 numeric values: mean TTP and TTP ratio. Comparison was made against 22 age and sex matched controls. Perfusion abnormalities were found, with a striking sex difference with men showing more pronounced perfusion abnormalities. Perfusion abnormalities correlated with self-rated dyspnea in men.

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