Meeting Banner
Abstract #0735

Lung perfusion disturbances detected with MRI in non-hospitalized post-COVID individuals with dyspnea, with sex difference.

Jimmy Zhou Yu1,2, Tobias Granberg2,3, Roya Shams2, Sven Petersson2, Adrian Szum2, Magnus Sköld4, Sven Nyrén1,2, and Johan Lundberg2,3
1Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm Solna, Sweden, 2Radiology department, Karolinska University Hospital, Stockholm, Sweden, 3Department of Neuroscience, Karolinska Institutet, Stockholm Solna, Sweden, 4Department of Medicine, Karolinska Institutet, Stockholm Solna, Sweden


Mechanisms underlying dyspnea in non-hospitalized patients with persistent post-COVID is unknown. Lung perfusion abnormalities have been reported in acute COVID-19, and may also be important in post-COVID. Dynamic contrast enhanced (DCE)-MRI [MS1] was applied to study lung perfusion in 28 non-hospitalized patients with persistent dyspnea 4-13 months post-COVID. Time-to-peak (TTP)[MS2] maps were numerically summarized as normalized as 2 numeric values: mean TTP and TTP ratio. Comparison was made against 22 age and sex matched controls. Perfusion abnormalities were found, with a striking sex difference with men showing more pronounced perfusion abnormalities. Perfusion abnormalities correlated with self-rated dyspnea in men.

This abstract and the presentation materials are available to members only; a login is required.

Join Here