Meeting Banner
Abstract #0736

Multinuclear lung MRI assessment of COVID-19 patients at 6 and 12 weeks after hospital admission

Laura C. Saunders1, Guilhem J. Collier1, Ho-Fung Chan1, Paul J. C. Hughes1, Laurie J. Smith1, Helen Marshall1, James A. Eaden1, Jody Bray1, David J. Capener1, Leanne Armstrong1, Jennifer Rodgers1, Martin Brook1, Alberto M. Biancardi1, James Watson2, Zoë Gabriel2, Madhwesha R. Rao1, Graham Norquay1, Oliver Rodgers1, Fred Wilson3, Tony Cahn3, Andy Swift1, Smitha Rajaram2, Fergus Gleeson4,5, James T. Grist5, Gary H. Mills2,6, James Meiring2, Lisa Watson2, Paul J. Collini6, Rod Lawson2, Roger Thompson1, and Jim M. Wild1
1Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 2Sheffield Teaching Hospitals, Sheffield, United Kingdom, 3GlaxoSmithKline, Stevenage, United Kingdom, 4Oxford NHS Foundation Trust, Oxford, United Kingdom, 5University of Oxford, Oxford, United Kingdom, 6University of Sheffield, Sheffield, United Kingdom

Synopsis

This work uses a multinuclear 1H and 129Xe protocol to assess pathophysiological changes in patients with COVID-19 pneumonia, without signs of interstitial lung disease, at 6 and 12 weeks after hospital admission. 1H and 129Xe protocol: ultra-short echo time, dynamic contrast enhanced lung perfusion, 129Xe lung ventilation, 129Xe diffusion weighted MRI, 129Xe 3D spectroscopic imaging. Though significant improvements in lung ventilation homogeneity (decreased low ventilation percentage and ventilation coefficient of variation), gas transfer (increased RBC:TP, decreased TP T2*) and perfusion (increased pulmonary blood volume and flow) were seen between 6 and 12 weeks, low RBC:TP ratio persisted for some patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords