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Abstract #0772

In vivo quantitative laminar R2* and susceptibility imaging at 0.3 mm in-plane resolution

Jiaen Liu1, Peter van Gelderen2, Xu Li3,4, Jacco A. de Zwart2, Kuo-Wei Lai4,5, Jeremias Sulam5, Erin S. Beck6, Serhat V. Okar2, Peter C.M. van Zijl3,4, Daniel S. Reich2, and Jeff H. Duyn2
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, 3Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States, 4F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 5Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 6Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Synopsis

High resolution submillimeter MRI of myelin and iron may enhance our capability to define neural diseases more accurately and at an earlier stage. Susceptibility-weighted MRI methods are intrinsically sensitive to myelin and iron and benefit from the increased contrast-to-noise ratio at 7 T. In this study, we systematically investigated R2* and susceptibility distributions in cortical layers of healthy subjects with 0.3 mm in-plane resolution and 0.4 mm slice thickness. This effort was facilitated by a robust navigator-based motion- and B0-corrected GRE sequence.

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Keywords