Abstract #0835

Usage of Dissolution DNP Magnetic Resonance Spectroscopy Depicts Efficacy of Chemotherapeutic and Radiotherapeutic Anticancer Interferences

Abdelazim Elsayed Elhelaly^1,2, Fuminori Hyodo¹, Norikazu Koyasu³, Hiroyuki Tomita⁴, Masaharu Murata⁵, Yoshifumi Noda³, Hiroki Kato³, and Masayuki Matsuo³

¹Department of Radiology, Frontier Science for Imaging, Gifu University, Gifu, Japan, ²Department of Food Hygiene and Control, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt, ³Department of Radiology, Gifu University, Gifu, Japan, ⁴Department of Tumor Pathology, Gifu University, Gifu, Japan, ⁵Innovation Center for Medical Redox Navigation, Kyushu University, Kyushu, Japan

Synopsis

DNP highly improves the sensitivity of magnetic resonance spectroscopy allowing for greater insight into in vivo metabolic activity. We used our dissolution ¹³C DNP system to monitor the Warburg effect in MIA PaCa human pancreatic carcinoma model mice subjected to radiotherapy or chemotherapy. In vivo production of ¹³C lactate in tumors showed a significant reduction after radiation therapy. Mice subjected to anticancer drugs also showed a significant reduction in the relative production of ¹³C lactate at an early stage of the treatment course before any anatomical changes in the structure or size of the tumors were detectable by MRI images.

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