DNP highly improves the sensitivity of magnetic resonance spectroscopy allowing for greater insight into in vivo metabolic activity. We used our dissolution 13C DNP system to monitor the Warburg effect in MIA PaCa human pancreatic carcinoma model mice subjected to radiotherapy or chemotherapy. In vivo production of 13C lactate in tumors showed a significant reduction after radiation therapy. Mice subjected to anticancer drugs also showed a significant reduction in the relative production of 13C lactate at an early stage of the treatment course before any anatomical changes in the structure or size of the tumors were detectable by MRI images.
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