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Abstract #0835

Usage of Dissolution DNP Magnetic Resonance Spectroscopy Depicts Efficacy of Chemotherapeutic and Radiotherapeutic Anticancer Interferences

Abdelazim Elsayed Elhelaly1,2, Fuminori Hyodo1, Norikazu Koyasu3, Hiroyuki Tomita4, Masaharu Murata5, Yoshifumi Noda3, Hiroki Kato3, and Masayuki Matsuo3
1Department of Radiology, Frontier Science for Imaging, Gifu University, Gifu, Japan, 2Department of Food Hygiene and Control, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt, 3Department of Radiology, Gifu University, Gifu, Japan, 4Department of Tumor Pathology, Gifu University, Gifu, Japan, 5Innovation Center for Medical Redox Navigation, Kyushu University, Kyushu, Japan


DNP highly improves the sensitivity of magnetic resonance spectroscopy allowing for greater insight into in vivo metabolic activity. We used our dissolution 13C DNP system to monitor the Warburg effect in MIA PaCa human pancreatic carcinoma model mice subjected to radiotherapy or chemotherapy. In vivo production of 13C lactate in tumors showed a significant reduction after radiation therapy. Mice subjected to anticancer drugs also showed a significant reduction in the relative production of 13C lactate at an early stage of the treatment course before any anatomical changes in the structure or size of the tumors were detectable by MRI images.

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