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Abstract #1072

In-vivo Imaging of hyperpolarized and purified Fumarate at 11.7 T

Tobias Speidel1, Stephan Knecht2, Martin Gierse2, Tobias Lobmeyer1, Gordon Winter3, Jessica Löffler3, Maximilian Fellermann4, Ilai Schwartz2, Holger Barth4, and Volker Rasche1
1Internal Medicine II, Ulm University Medical Center, Ulm, Germany, 2NVision Imaging Technologies GmbH, Ulm, Germany, 3Department of Nuclear Medicine, Ulm University Medical Center, Ulm, Germany, 4Institute for Pharmacology and Toxicology, Ulm University Medical Center, Ulm, Germany


Hyperpolarized [1-13C] fumarate has been shown to be a reliable imaging biomarker for monitoring cellular necrosis with conversion of [1-13C]fumarate to [1-13C]malate via Fumarate hydratase. However, the inherently low 13C-sensitivity limits biomedical applications with a need for accessible and low-cost hyperpolarization methods.

In this abstract we show that parahydrogen-induced polarization methods can overcome these limitations by providing highly polarized and purified [1-13C]fumarate as a non-toxic perfusion agent with the capabilities of acting as a biomarker of cell necrosis in metabolic 13C MRI.

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