Hyperpolarized [1-13C] fumarate has been shown to be a reliable imaging biomarker for monitoring cellular necrosis with conversion of [1-13C]fumarate to [1-13C]malate via Fumarate hydratase. However, the inherently low 13C-sensitivity limits biomedical applications with a need for accessible and low-cost hyperpolarization methods.
In this abstract we show that parahydrogen-induced polarization methods can overcome these limitations by providing highly polarized and purified [1-13C]fumarate as a non-toxic perfusion agent with the capabilities of acting as a biomarker of cell necrosis in metabolic 13C MRI.
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