Abstract #1073

Reproducibility of multi-slice MR spectroscopic imaging of GABA at 3 T

Helge Jörn Zöllner¹, Ipek Özdemir¹, Dillip K. Senapati¹, Michal Považan², Georg Oeltzschner¹, Kimberly Chan³, Doris D. M. Lin¹, and Peter B. Barker^1,4

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²3 Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Copenhagen, Denmark, ³Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁴F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Reproducibility of multi-slice GABA-edited MRSI of the human brain recorded at 3T was investigated in 6 healthy adult volunteers, with and without a retrospective motion compensation scheme applied (MoCo). Overall reproducibility was good with improved performance when MoCo was applied (relative GABA+/tCr difference between visits: 20.8% no Moco, 10.0% with MoCo). Retrospective MoCo is a viable alternative for edited-MRSI when prospective motion correction is unavailable, at least in relatively compliant subject groups.

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