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Abstract #1073

Reproducibility of multi-slice MR spectroscopic imaging of GABA at 3 T

Helge Jörn Zöllner1, Ipek Özdemir1, Dillip K. Senapati1, Michal Považan2, Georg Oeltzschner1, Kimberly Chan3, Doris D. M. Lin1, and Peter B. Barker1,4
1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 23 Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Copenhagen, Denmark, 3Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States


Reproducibility of multi-slice GABA-edited MRSI of the human brain recorded at 3T was investigated in 6 healthy adult volunteers, with and without a retrospective motion compensation scheme applied (MoCo). Overall reproducibility was good with improved performance when MoCo was applied (relative GABA+/tCr difference between visits: 20.8% no Moco, 10.0% with MoCo). Retrospective MoCo is a viable alternative for edited-MRSI when prospective motion correction is unavailable, at least in relatively compliant subject groups.

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