Abstract #1074

Investigating liver fibrosis using water T1 estimated by flip angle corrected multi-parameter MRS

Ashley L Louie¹, Gavin Hamilton¹, Alexandra N Schlein¹, Walter C Henderson¹, Danielle N Batakis¹, Lael K Ceriani¹, Yesenia Covarrubias¹, Tanya Wolfson¹, Nikolaos Panagiotopolous², David T Harris², McMillan Alan², Daiki Tamada², Kathryn J Fowler¹, Scott B Reeder², and Claude B Sirlin¹

¹Radiology, University of California, San Diego, La Jolla, CA, United States, ²Radiology, University of Wisconsin, Madison, WI, United States

Synopsis

The purpose of this study was to examine the relationship between water T1 and T2 estimated by Flip Angle Corrected Multi-Parameter (CMP) MRS and biopsy-determined fibrosis. The sample of twenty-eight subjects with biopsy and MRS data is part of a dual-center, weight loss surgery study. Subjects without fibrosis were found to have significantly higher CMP MRS T1 water values than patients with fibrosis.

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