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Abstract #1074

Investigating liver fibrosis using water T1 estimated by flip angle corrected multi-parameter MRS

Ashley L Louie1, Gavin Hamilton1, Alexandra N Schlein1, Walter C Henderson1, Danielle N Batakis1, Lael K Ceriani1, Yesenia Covarrubias1, Tanya Wolfson1, Nikolaos Panagiotopolous2, David T Harris2, McMillan Alan2, Daiki Tamada2, Kathryn J Fowler1, Scott B Reeder2, and Claude B Sirlin1
1Radiology, University of California, San Diego, La Jolla, CA, United States, 2Radiology, University of Wisconsin, Madison, WI, United States


The purpose of this study was to examine the relationship between water T1 and T2 estimated by Flip Angle Corrected Multi-Parameter (CMP) MRS and biopsy-determined fibrosis. The sample of twenty-eight subjects with biopsy and MRS data is part of a dual-center, weight loss surgery study. Subjects without fibrosis were found to have significantly higher CMP MRS T1 water values than patients with fibrosis.

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