The PHIP-X methodology is a novel approach to hyperpolarize nuclei from specific molecules that could function as contrast agents in metabolic MRI. PHIP-X combines the strong polarization of hydrogenative PHIP with the broad applicability of proton exchange and opens up the variety of potential hyperpolarizable biomolecules. The presented experimental setup facilitates the application of pH2 pressures up to 30 bar and well-defined external magnetic fields up to 80 mT. Using this setup allowed to hyperpolarize glucose (830 mM) and achieved increasing polarization with increasing the pressure from 10 bar to 20 bar (molar polarization was more than doubled).
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