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Abstract #1076

GABA-edited MEGA-PRESS at 3T: Does a measured MM background improve linear-combination modeling?

Helge Jörn Zöllner1,2, Yulu Song1,2, Steve C. N. Hui1,2, Peter B. Barker1,2, Richard A. E. Edden1,2, and Georg Oeltzschner1,2
1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Recent work identified a 'best practice' linear-combination modeling (LCM) strategy for GABA-edited spectra using parameterized basis functions for co-edited macromolecules. Here we introduce a measured macromolecular basis function to evaluate possible improvements in the modeling.

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