Abstract #1131

Signal-to-noise requirements for accurate and precise perfusion parameter estimation with pulsed arterial spin labeling MRI in skeletal muscle

Donnie Cameron^1,2, Thom T.J. Veeger¹, Esther J. Schrama³, Celine Baligand⁴, Lydiane Hirschler¹, Matthias J.P. van Osch¹, and Hermien E. Kan¹

¹C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Norwich Medical School, University of East Anglia, Norwich, United Kingdom, ³Department of Neurology, Leiden University Medical Center, Leiden, Netherlands, ⁴Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France

Synopsis

To develop perfusion applications in neuromuscular diseases, we examined the SNR and noise sensitivity of pulsed ASL for estimating microvascular reactivity and perfusion in skeletal muscle. We determined muscle blood flow and arterial transit time in volunteers after exercise and used these to inform simulations to establish the minimum ASL SNR required for accurate and precise perfusion parameter estimation. We observed a peak SNR of 10 in the tibialis anterior muscle. Simulations indicated that SNR>6 is sufficient for accurate parameter estimation, while SNR>12 is preferred for good precision. These findings will inform future exercise ASL protocol development in patient cohorts.

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