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Abstract #1285

An iterative algorithm for resolving high-resolution 23Na Multi-Quantum Coherences MRI from prior 1H constraints

Christian Licht1, Lothar R. Schad1, and Stanislas Rapacchi2
1Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany, 2CRMBM, Aix Marseille University, CNRS, Marseille, France


Sodium (23Na) MRI offers great potentials to be a clinical marker for disease states. Besides the single quantum signal, the triple quantum signal of 23Na could provide novel and complementary information. 3D volumetric 23Na multi-quantum coherences imaging, however, suffers from poor signal-to-noise ratios, which limit spatial resolution. Finer structures such as tissue boundaries are therefore barely observable. In addition, partial volume effects become more severe and diminish image quality as well as diagnostic applicability. The purpose of this work is to develop a reconstruction framework that addresses these shortcomings of 23Na multi-quantum coherences imaging by utilizing 1H prior constraints.

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