Abstract #1294

Multiparametric MRI, sodium MRI, and PSMA PET of prostate cancer with histological validation of Gleason grade

Josephine Tan¹, Alireza Akbari¹, Matthew Fox², Mena Gaed³, Madeleine Moussa⁴, Jose A Gomez⁴, Zahra Kassam⁵, William Pavlosky⁵, Joseph L Chin⁶, Stephen Pautler⁶, Nicholas Power⁶, Aaron D Ward^1,2, Glenn S Bauman^1,2, Jonathan D Thiessen^1,2,5, and Timothy J Scholl^1,3,7

¹Medical Biophysics, University of Western Ontario, London, ON, Canada, ²Lawson Health Research Institute, London, ON, Canada, ³Robarts Research Institute, University of Western Ontario, London, ON, Canada, ⁴Pathology and Laboratory Medicine, University of Western Ontario, London, ON, Canada, ⁵Medical Imaging, University of Western Ontario, London, ON, Canada, ⁶Surgery, Division of Urology, University of Western Ontario, London, ON, Canada, ⁷Ontario Institute for Cancer Research, Toronto, ON, Canada

Synopsis

This abstract focuses on the development of an imaging assay based on multiparametric MRI and sodium (²³Na) MRI to discriminate between low- and high-grade prostate cancer (PCa) lesions, using Gleason grade defined by whole-mount histopathology as the gold standard and PET targeting the prostate-specific membrane antigen (PSMA) as a validation. Data from the first patient (Gleason score 7) demonstrates that PSMA-PET may be superior in detecting PCa lesions in the transition zone and distant metastases while the sensitivity of the current ²³Na radiofrequency system in this study is limited to lesions in the peripheral zone of the prostate.

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