Age Dependent Changes of Water Exchange Rate in Blood Brain Barrier (BBB) Assessed by Diffusion-Prepared Arterial Spin Labeling
Qinyang Shou1, Xingfeng Shao1, Kimberly Felix2, Brandon Ojogho1, Xuejuan Jiang2,3, Megan M Herting2, and Danny JJ Wang1
1Laboratory of Functional MRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, 2Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 3Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
The purpose of this study was to investigate the relationship between water exchange rate (kw) of blood brain barrier and age. Diffusion Prepared pCASL technique was used to measure kw in four datasets with a wide range of age (8 to 81 years). Global and regional kw values as well as cerebral blood flow and arterial transit time were analyzed. The results show an overall trend of decreasing kw with age, in parietal and parahippocampal regions there are U-shaped and inverted U-shaped changes of kw with age.
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