Abstract #1295

Age Dependent Changes of Water Exchange Rate in Blood Brain Barrier (BBB) Assessed by Diffusion-Prepared Arterial Spin Labeling

Qinyang Shou¹, Xingfeng Shao¹, Kimberly Felix², Brandon Ojogho¹, Xuejuan Jiang^2,3, Megan M Herting², and Danny JJ Wang¹

¹Laboratory of Functional MRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, ²Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ³Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States

Synopsis

The purpose of this study was to investigate the relationship between water exchange rate (kw) of blood brain barrier and age. Diffusion Prepared pCASL technique was used to measure kw in four datasets with a wide range of age (8 to 81 years). Global and regional kw values as well as cerebral blood flow and arterial transit time were analyzed. The results show an overall trend of decreasing kw with age, in parietal and parahippocampal regions there are U-shaped and inverted U-shaped changes of kw with age.

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