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Abstract #1312

Towards non-invasive assessment of cardiovascular physiology by combining cardiac MRI with predictive biomechanical modeling

Rebecca Waugh1,2, Maria Gusseva3,4, Gerald Greil2, Dominique Chapelle3,4, Tarique Hussain2, and Radomir Chabiniok2
1UT Dallas, Dallas, TX, United States, 2Pediatrics, UT Southwestern Medical Center, Dallas, TX, United States, 3Inria, Palaiseau, France, 4LMS, Ecole Polytechnique, Palaiseau, France


Biomechanical models coupled with cardiovascular MRI (CMR) have the potential to provide non-invasively physiological parameters of clinical interest. The approach is presented and validated on a group of 10 patients who underwent CMR and invasive catheterization. Patient-specific models are built based on CMR data and maximum/minimum arterial pressure. The stroke work, derived from ventricular pressure-volume (P-V) loops, was comparable between the measured and simulated P-V loops, suggesting the high quality of the in silico loops. An excellent correlation of the model-derived myocardial contractility with maximum time-derivative of ventricular pressure gives an opportunity for the non-invasive characterization of patients’ inotropic state.

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