Diffusion-weighted MRI is a highly sensitive to alteration in the movement of water molecules and allows the assessment of various pathologies. Interpretation of the changes can be obscured by signal-dropout due to tissue-air susceptibility difference at the boundaries of nasal cavities, especially in the prefrontal region. The head tilting (chin-up) method during the brain scan could be considered as an accessible way without additional hardware- or sequence to prevent those susceptibility-induced signal-dropout. We demonstrated DWI with head-tilting (up to 20°) resulted in had less severe signal dropout and improved image quality than normal scan in the prefrontal cortex.
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