Characterizing Heterogeneity of Gliomas with a Fractional-order Calculus Diffusion Model
Wenbo Sun1, Dan Xu1, Yunfei Zhang2, Yongming Dai2, and Haibo Xu1
1Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China, 2Central Research Institute, United Imaging Healthcare, Shanghai, China
This study aimed to investigate whether the FROC diffusion model could help predict molecular biomarkers in gliomas. It was found that FROC has the potential in comprehensively characterizing heterogeneity of gliomas, not only in glioma grading, but also in predicting tumor cell proliferation rate and isocitrate dehydrogenase-1 (IDH-1) gene mutation status.
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