Impact of Acute Intermittent Hypoxia on BOLD fMRI measures of cerebrovascular reactivity
Mark Andrew Hoggarth1, Rachael C Stickland1, Kimberly J Hemmerling2, Milap Sandhu3,4, and Molly G Bright1,2
1Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, United States, 2Biomedical Engineering, Northwestern University, Chicago, IL, United States, 3Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL, United States, 4Shirley Ryan AbilityLab, Chicago, IL, United States
We assess the effects of an emerging intervention for rehabilitation, termed acute intermittent hypoxia (AIH), on cerebrovascular reactivity (CVR) as measured with BOLD fMRI. Lag-optimized CVR was measured pre- and post-AIH using a breath-hold task paradigm in 8 healthy participants. Five participants achieved the target drop in oxygen saturation (SpO2) to 85%; 3 did not. Overall changes in group mean CVR were varied following AIH, slightly increasing for those who achieved the targeted SpO2, and decreasing in those who did not. This work motivates continued study of the effects of AIH interventions on CVR.
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