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Abstract #1772

Disruptions of functional and structural networks in classic trigeminal neuralgia patients

Pengfei Zhang1, Jun Wang1, Wanjun Hu1, Laiyang Ma1, Guangyao Liu1, Kai Ai2, and Jing Zhang1
1Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China, 2Philips Healthcare, Xi'an, China


Classic trigeminal neuralgia (CTN) has been proven related to functional or morphological alterations in critical brain regions. To test the simultaneous changes of the topological properties of structural networks (SN), functional networks (FN), as well as their couplings, we constructed SN using diffusion tensor imaging (DTI) data and FN using resting-state functional magnetic imaging (rs-fMRI) data from 29 CTN patients and 34 healthy controls (HCs). The patients showed the wide disruptions of global and local topological organizations in SN and FN, together with the abnormal coupling relationships. Our findings may provide novel perspectives for understanding the pathophysiological mechanisms of CTN.

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