Classic trigeminal neuralgia (CTN) has been proven related to functional or morphological alterations in critical brain regions. To test the simultaneous changes of the topological properties of structural networks (SN), functional networks (FN), as well as their couplings, we constructed SN using diffusion tensor imaging (DTI) data and FN using resting-state functional magnetic imaging (rs-fMRI) data from 29 CTN patients and 34 healthy controls (HCs). The patients showed the wide disruptions of global and local topological organizations in SN and FN, together with the abnormal coupling relationships. Our findings may provide novel perspectives for understanding the pathophysiological mechanisms of CTN.
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